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This comprehensive book focuses on multimodality imaging technology, including overviews of the instruments and methods followed by practical case studies that highlight use in the detection and treatment of cardiovascular diseases. Chapters cover PET-CT, SPECT-CT, SPECT-MRI, PET-MRI, PET-optical imaging, SPECT-optical imaging, photoacoustic Imaging, and hybrid intravascular imaging. It also addresses the important issues of multimodality imaging probes and image quantification. Readers from radiology and cardiology as well as medical imaging and biomedical engineering will learn essentials of the field. They will be shown how the field has advanced quantitative analysis of molecularly targeted imaging through improvements in the reliability and reproducibility of imaging data. Moreover, they will be presented with quantification algorithms and case illustrations, including coverage of such topics such as multimodality image fusion and kinetic modeling. Yi-Hwa Liu, PhD is Senior Research Scientist in Cardiovascular Medicine at Yale University School of Medicine and Technical Director of Nuclear Cardiology at Yale New Haven Hospital. He is also an Associate Professor (Adjunct) of...

Cardiovascular and Neurovascular Imaging: Physics and Technology explains the underlying physical and technical principles behind a range of cardiovascular and neurovascular imaging modalities, including radiography, nuclear medicine, ultrasound, and magnetic resonance imaging (MRI). Examining this interdisciplinary branch of medical imaging from a

Improve the Accurate Detection and Diagnosis of Cancer and Other Diseases Despite the expansion of the CAD field in recent decades, there is currently no single book dedicated to the development and use of CAD systems. Filling this need, Computer-Aided Detection and Diagnosis in Medical Imaging covers the major technical advances and methodologies shaping the development and clinical utility of CAD systems in breast imaging, chest imaging, abdominal imaging, and other emerging applications. After a historical overview of CAD, the book is divided into four sections. The first section presents CAD technologies in breast imaging, which is the most advanced area of CAD application. The second section discusses CAD technologies in chest and abdominal imaging. The third section explores emerging CAD technologies in a wide range of imaging modalities designed to address a variety of diseases. The final section describes the current use of CAD systems in clinical practice as well as how CAD will play an important role in quantitative image biomarkers and imaging genomics research. This book brings together existing and emerging CAD approaches at a level understandable to students, CAD...

An innovative, three-dimensional x-ray imaging technique that enhances projection radiography by adding depth resolution, Tomosynthesis Imaging explores tomosynthesis, an emerging limited-angle tomographic imaging technology that is being considered for use in a range of clinical applications, and is currently being used for breast cancer screening and diagnosis. While conventional mammography has been very successful in reducing breast cancer mortality, it is not perfect. A major limitation of mammography is that the recorded image represents the superposition of complex three-dimensional structures in the breast onto a two-dimensional plane, making detection and diagnosis of breast cancer challenging. Tomosynthesis produces quasi-three-dimensional images that can significantly enhance the visualization of important diagnostic features. This book highlights the flexibility of tomosynthesis systems for new clinical applications, and provides a detailed discussion of the tomosynthesis acquisition process and the impact of physical factors. It explores such topics as acquisition parameters, system components, modeling, image reconstruction algorithms, and system evaluation. Provides ...

The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans. Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research. The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate...

Written by internationally known experts in the field, Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy examines one of the fastest-developing subspecialties within radiation oncology. These procedures deliver large doses of radiation in one to five sessions to a precisely determined target. Often these techniques have proven to be as or more effective than traditional radiation therapy techniques, while at the same time being cost-efficient and convenient for the patient. These techniques, however, require careful planning, specialized equipment, and well-trained staff. This volume provides a cutting-edge look at the biological and technical underpinnings of SRS and SBRT techniques. It includes a history of the development of SRS and SBRT; clinical applications of the techniques; dedicated devices for delivering precisely shaped, high doses of radiation; use of in-room imaging for treatment planning and treatment guidance; immobilization techniques for accurate targeting; and future developments that will continue to evolve and refine existing techniques. A valuable introduction to those just learning about these specialized techniques, and an ideal reference for ...

Conventional computed tomography (CT) techniques employ a narrow array of x-ray detectors and a fan-shaped x-ray beam to rotate around the patient to produce images of thin sections of the patient. Large sections of the body are covered by moving the patient into the rotating x-ray detector and x-ray source gantry. Cone beam CT is an alternative technique using a large area detector and cone-shaped x-ray beam to produce 3D images of a thick section of the body with one full angle (360 degree or 180 degree plus detector coverage) rotation. It finds applications in situations where bulky, conventional CT systems would interfere with clinical procedures or cannot be integrated with the primary treatments or imaging systems. Cone Beam Computed Tomography explores the past, present, and future state of medical x-ray imaging while explaining how cone beam CT, with its superior spatial resolution and compact configuration, is used in clinical applications and animal research. The book: Supplies a detailed introduction to cone beam CT, covering basic principles and applications as well as advanced techniques Explores state-of-the-art research and future developments while examining the...

Up-to-Date Details on Using Ultrasound Imaging to Help Diagnose Various Diseases Due to improvements in image quality and the reduced cost of advanced features, ultrasound imaging is playing a greater role in the diagnosis and image-guided intervention of a wide range of diseases. Ultrasound Imaging and Therapy highlights the latest advances in using ultrasound imaging in image-guided interventions and ultrasound-based therapy. The book presents current and emerging techniques, identifies trends in the use of ultrasound imaging, and addresses technical and computational problems that need to be solved. The book is organized into three sections. The first section covers advances in technology, including transducers (2-D, 3-D, and 4-D), beamformers, 3-D imaging systems, and blood velocity estimation systems. The second section focuses on diagnostic applications, such as elastography, quantitative techniques for therapy monitoring and diagnostic imaging, and ultrasound tomography. The final section explains the use of ultrasound in image-guided interventions for image-guided biopsy and brain imaging.

Radiomics and Radiogenomics: Technical Basis and Clinical Applications provides a first summary of the overlapping fields of radiomics and radiogenomics, showcasing how they are being used to evaluate disease characteristics and correlate with treatment response and patient prognosis. It explains the fundamental principles, technical bases, and clinical applications with a focus on oncology. The book’s expert authors present computational approaches for extracting imaging features that help to detect and characterize disease tissues for improving diagnosis, prognosis, and evaluation of therapy response. This book is intended for audiences including imaging scientists, medical physicists, as well as medical professionals and specialists such as diagnostic radiologists, radiation oncologists, and medical oncologists. Features Provides a first complete overview of the technical underpinnings and clinical applications of radiomics and radiogenomics Shows how they are improving diagnostic and prognostic decisions with greater efficacy Discusses the image informatics, quantitative imaging, feature extraction, predictive modeling, software tools, and other key areas Covers applications ...

Radioembolization is a widely used treatment for non-resectable primary and secondary liver cancer. This handbook addresses the radiation biology, physics, nuclear medicine, and imaging for radioembolization using Yttrium-90 (90Y) microspheres, in addition to discussing aspects related to interventional radiology. The contents reflect on and off-label treatment indications, dose-response relationships, treatment-planning, therapy optimization, radiation safety, imaging follow-up and many other facets of this therapy necessary for both novice and advanced users alike.

Scintillation Dosimetry delivers a comprehensive introduction to plastic scintillation dosimetry, covering everything from basic radiation dosimetry concepts to plastic scintillating fiber optics. Comprised of chapters authored by leading experts in the medical physics community, the book: Discusses a broad range of technical implementations, from point source dosimetry scaling to 3D-volumetric and 4D-scintillation dosimetry Addresses a wide scope of clinical applications, from machine quality assurance to small-field and in vivo dosimetry Examines related optical techniques, such as optically stimulated luminescence (OSL) or Čerenkov luminescence Thus, Scintillation Dosimetry provides an authoritative reference for detailed, state-of-the-art information on plastic scintillation dosimetry and its use in the field of radiation dosimetry.

Thoroughly updated throughout, this second edition of Monte Carlo Techniques in Radiation Therapy: Applications to Dosimetry, Imaging, and Preclinical Radiotherapy, edited by Joao Seco and Frank Verhaegen, explores the use of Monte Carlo methods for modelling various features of internal and external radiation sources. Monte Carlo methods have been heavily used in the field of radiation therapy in applications such as dosimetry, imaging, radiation chemistry, modelling of small animal irradiation units, etc. The aim of this book is to provide a compendium of the Monte Carlo methods that are commonly used in radiation therapy applications, which will allow students, postdoctoral fellows, and university professors to learn and teach Monte Carlo techniques. This book provides concise but detailed information about many Monte Carlo applications that cannot be found in any other didactic or scientific book. This second edition contains many new chapters on topics such as: Monte Carlo studies of prompt gamma emission Developments in proton imaging Monte Carlo for cone beam CT imaging Monte Carlo modelling of proton beams for small animal irradiation Monte Carlo studies of microbeam...

Big Data in Radiation Oncology gives readers an in-depth look into how big data is having an impact on the clinical care of cancer patients. While basic principles and key analytical and processing techniques are introduced in the early chapters, the rest of the book turns to clinical applications, in particular for cancer registries, informatics, radiomics, radiogenomics, patient safety and quality of care, patient-reported outcomes, comparative effectiveness, treatment planning, and clinical decision-making. More features of the book are: Offers the first focused treatment of the role of big data in the clinic and its impact on radiation therapy. Covers applications in cancer registry, radiomics, patient safety, quality of care, treatment planning, decision making, and other key areas. Discusses the fundamental principles and techniques for processing and analysis of big data. Address the use of big data in cancer prevention, detection, prognosis, and management. Provides practical guidance on implementation for clinicians and other stakeholders. Dr. Jun Deng is a professor at the Department of Therapeutic Radiology of Yale University School of Medicine and an ABR board...

About ten years after the first edition comes this second edition of Monte Carlo Techniques in Radiation Therapy: Introduction, Source Modelling, and Patient Dose Calculations, thoroughly updated and extended with the latest topics, edited by Frank Verhaegen and Joao Seco. This book aims to provide a brief introduction to the history and basics of Monte Carlo simulation, but again has a strong focus on applications in radiotherapy. Since the first edition, Monte Carlo simulation has found many new applications, which are included in detail. The applications sections in this book cover the following: Modelling transport of photons, electrons, protons, and ions Modelling radiation sources for external beam radiotherapy Modelling radiation sources for brachytherapy Design of radiation sources Modelling dynamic beam delivery Patient dose calculations in external beam radiotherapy Patient dose calculations in brachytherapy Use of artificial intelligence in Monte Carlo simulations This book is intended for both students and professionals, both novice and experienced, in medical radiotherapy physics. It combines overviews of development, methods, and references to facilitate Monte Carlo...

A host of imaging techniques are available to clinical cardiologists, including nuclear imaging, echocardiography, computerized tomography, and magnetic-resonance imaging. Chamber size, ventricular function, valvular function, coronary anatomy, and myocardial perfusion are among a wide array of cardiac characteristics that can all be assessed noninvasively. Cardiovascular Imaging systematically reviews each of these major techniques and provides clinical data from well-designed research studies. Following a brief overview of non-invasive cardiac imaging and the stress modalities used to detect coronary disease, case-based chapters are devoted to each of the various imaging techniques. The final chapter provides a glimpse of future possibilities, particularly with respect to molecular imaging. The text is illustrated throughout with amply-sized images. Demonstrating the values and limitations of the imaging techniques, the book enables practitioners to determine which test, in which patient population, and for which purpose would be the most appropriate to use.

The two-volume set LNCS 3749 and LNCS 3750 constitutes the refereed proceedings of the 8th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2005, held in Palm Springs, CA, USA, in October 2005. Based on rigorous peer reviews the program committee selected 237 carefully revised full papers from 632 submissions for presentation in two volumes. The first volume includes all the contributions related to image analysis and validation, vascular image segmentation, image registration, diffusion tensor image analysis, image segmentation and analysis, clinical applications - validation, imaging systems - visualization, computer assisted diagnosis, cellular and molecular image analysis, physically-based modeling, robotics and intervention, medical image computing for clinical applications, and biological imaging - simulation and modeling. The second volume collects the papers related to robotics, image-guided surgery and interventions, image registration, medical image computing, structural and functional brain analysis, model-based image analysis, image-guided intervention: simulation, modeling and display, and image segmentation and analysis.

This book offers readers a comprehensive introduction to the techniques and application of 3D printing in cardiovascular medicine. To do so, it addresses the history, concepts, and methods of 3D printing, choice of printing materials for clinical purposes, personalized planning of cardiac surgery and transcatheter interventions with patient-specific models, enhancement of patient-physician communication, simulation of endovascular procedures, and advances in 3D bio-printing. The book particularly focuses on the application of 3D printing to improve the efficacy and safety of cardiac interventions, and to promote the realization of precision medical care. The book gathers contributions by an international team of experts in the field of cardiovascular medicine, who combine the latest findings with their own practical experience in using 3D printing to support the diagnosis and treatment of a wide range of cardiovascular diseases. They present in-depth discussions in the fields of congenital heart disease, valvular disease, coronary artery disease, cardiomyopathy, left atrial appendage occlusion, cardiac tumors and vascular diseases.

Issues for 1973- cover the entire IEEE technical literature.

Drug Delivery Devices and Therapeutic Systems examines the current technology and innovations moving drug delivery systems (DDS) forward. The book provides an overview on the therapeutic use of drug delivery devices, including design, applications, and a description of the design of each device. While other books focus on the therapy, the primary emphasis in this book is on current technologies for DDS applications, including microfluidics, nanotechnology, biodegradable hydrogel and microneedles, with a special emphasis on wearable DDS. As part of the Developments in Biomedical Engineering and Bioelectronics series, this book is written by experts in the field and informed with information directly from manufacturers. Pharmaceutical scientists, medical researchers, biomedical engineers and clinical professionals will find this an essential reference. Provides essential information on the most recent drug delivery systems available Explains current technology and its applications to drug delivery Contains contributions from biomedical engineers, pharmaceutical scientists and manufacturers

Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.